Journal article
Neuroimaging differences between older adults with maintained versus declining cognition over a 10-year period
C Rosano, HJ Aizenstein, AB Newman, V Venkatraman, T Harris, J Ding, S Satterfield, K Yaffe
Neuroimage | Published : 2012
Abstract
Background: Maintaining cognitive function protects older adults from developing functional decline. This study aims to identify the neuroimaging correlates of maintenance of higher global cognition as measured by the Modified Mini Mental State Test (3MS) score. Methods: Repeated 3MS measures from 1997-98 through 2006-07 and magnetic resonance imaging with diffusion tensor in 2006-07 were obtained in a biracial cohort of 258 adults free from dementia (mean age 82.9. years, 56% women, 42% blacks). Participants were classified as having shown either maintenance (3MS slope > 0) or decline (3MS slope < 1. SD below the mean) of cognition using linear mixed models. Measures of interest were white ..
View full abstractGrants
Awarded by National Institutes of Health
Funding Acknowledgements
This research was supported by grant nos. N01-AG-6-2101, N01-AG-6-2103, N01-AG-6-2106. This research was also supported in part by the Intramural Research Program of the NIH, National Institute on Aging. (K23 AG 028966, R01 AG 029232).