Journal article

Vaccine potential of attenuated mutants of Corynebacterium pseudotuberculosis in sheep

CP Simmons, SJ Dunstan, M Tachedjian, J Krywult, ALM Hodgson, RA Strugnell

INFECTION AND IMMUNITY | AMER SOC MICROBIOLOGY | Published : 1998

Abstract

Corynebacterium pseudotuberculosis, a gram-positive facultative intracellular bacterial pathogen, is the etiological agent of the economically important disease caseous lymphadenitis (CLA) in both sheep and goats. Attenuated mutants of C. pseudotuberculosis have the potential to act as novel vaccines against CLA and as veterinary vaccine vectors. In this report, we have assessed the virulence of both aroQ and pld mutants of C. pseudotuberculosis in sheep and concurrently their capacity to act as vaccines against homologous challenge. The results suggest that aroQ mutants of C. pseudotuberculosis are attenuated with regard to both lymph node persistence and vaccination site reactogenicity. Im..

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