A mixed model for analyses of data on multiple genetic markers.

Abstract

Data on a genetic marker linked to a gene affecting an important trait could help us to estimate breeding values for that trait more accurately. The accuracy is enhanced if many genetic markers are used and if important genes are bracketed by two markers. A mixed model for analysis of this type of data is presented. The model is appropriate for an arbitrary pedigree structure in an outbreeding species. It uses a "relationship" matrix among marked chromosome segments or QTL alleles. By using an analysis analogous to a reduced animal model, the number of effects to be estimated can be greatly reduced. A grouping strategy that can account for crossbreeding and linkage disequilibrium between mar..