Conference Proceedings

Thymic myoid cells as a source of cells for myoblast transfer

CN Pagel, JE Morgan, JG Gross, TA Partridge

Cell Transplantation | SAGE PUBLICATIONS INC | Published : 2000

Abstract

Transplantation of disaggregated myoblasts from normal donor to the muscles of a diseased host, or reimplantation of genetically modified host myoblasts, has been suggested as a possible route to therapy for inherited myopathies such as Duchenne muscular dystrophy, or to supply missing proteins that are required systemically in diseases such as hemophilia. With two exceptions, studies of myoblast transfer in the mouse have involved transplantation of donor myoblasts isolated from adult or neonatal skeletal muscle satellite cells. In this study we present evidence that thymic myoid cells are capable of participating in the regeneration of postnatal skeletal muscle, resulting in the expression..

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University of Melbourne Researchers