Journal article
Mechano-logical model of C. Elegans germ line suggests feedback on the cell cycle
K Atwell, Z Qin, D Gavaghan, H Kugler, EJA Hubbard, JM Osborne
Development Cambridge | Published : 2015
DOI: 10.1242/dev.126359
Abstract
The Caenorhabditis elegans germ line is an outstanding model system in which to study the control of cell division and differentiation. Although many of the molecules that regulate germ cell proliferation and fate decisions have been identified, how these signals interact with cellular dynamics and physical forces within the gonad remains poorly understood. We therefore developed a dynamic, 3D in silico model of the C. elegans germ line, incorporating both the mechanical interactions between cells and the decision-making processes within cells. Our model successfully reproduces key features of the germ line during development and adulthood, including a reasonable ovulation rate, correct sper..
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Awarded by NIH Office of the Director
Funding Acknowledgements
K.A. and H.K. acknowledge support from Microsoft Research Cambridge. K.A. is supported by a grant from the Engineering and Physical Sciences Research Council (EPSRC) [EP/G037280/1] to the SABS Industrial Doctoral Centre; and acknowledges the use of Advanced Research Computing (ARC) resources. E.J.A.H. and Z.Q. acknowledge support from the National Institutes of Health (NIH) [R01GM61706 to E.J. A.H.]. Some strains were provided by the Caenorhabditis Genetics Center, which is funded by NIH Office of Research Infrastructure Programs [P40 OD010440]. J.M.O. and D.G. acknowledge support from the EPSRC and Microsoft Research Cambridge [EP/I017909/1]. Deposited in PMC for immediate release.