Proteomics of the human endometrium and uterine fluid: a pathway to biomarker discovery
Lois A Salamonsen, Tracey Edgell, Luk JF Rombauts, Andrew N Stephens, David M Robertson, Adam Rainczuk, Guiying Nie, Natalie J Hannan
Fertility and Sterility | ELSEVIER SCIENCE INC | Published : 2013
Failure of the endometrium to achieve receptivity results in infertility, and it is also a rate-limiting step in in vitro fertilization (IVF) success. The microenvironments provided by the endometrium during the receptive phase and that support implantation are highly complex and constantly changing as implantation progresses. Although a number of gene array studies have defined mRNA changes across the cycle, with infertility, and in IVF cycles, these have not generally been informative due in part to the subsequent regulation of transcription and posttranslational modifications of the proteins. State-of-the-art proteomic technologies now enable analysis of changes in the endometrium and its..View full abstract
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L.A.S. has received grants from NHMRC (Australia), Monash IVF, and Merck Serono GFI (unrelated to this work). T.E. received a Merck Serono Grant for Fertility Innovation Award after completion of the work reported in this review, an NHMRC project grant pending application for further work to identify uterine receptivity markers, and a grant awarded by Monash IVF Education and Research Foundation to undertake research into uterine receptivity markers (2011-2012 and 2012-2013), and also plans to patent in the field of uterine receptivity biomarkers. L.J.F.R. has consulted with MSD (not related to this work) and received a travel grant (not related to this work). A.N.S. has nothing to disclose. D.M.R. has nothing to disclose. A.R. has nothing to disclose. G.N. has nothing to disclose. N.J.H. has nothing to disclose.