PC6 levels in uterine lavage are closely associated with uterine receptivity and significantly lower in a subgroup of women with unexplained infertility
Sophea Heng, Natalie J Hannan, Luk JF Rombauts, Lois A Salamonsen, Guiying Nie
Human Reproduction | OXFORD UNIV PRESS | Published : 2011
BACKGROUND Embryo implantation requires a healthy embryo and a receptive uterus. Uterine incompetence contributes significantly to implantation failure and infertility. To date, there are no reliable biochemical methods that can determine whether the uterus is receptive. Proprotein convertase 5/6 (PC6) is tightly regulated in the uterus and critical for receptivity and implantation; its secretory nature predicts PC6 to be secreted into the uterine cavity. The present study examines whether PC6 is detectable in uterine lavage and whether there is any correlation between secreted PC6 levels and uterine receptivity. METHODS Western blotting determined the presence of PC6 protein in uterine lava..View full abstract
Awarded by National Health and Medical Research Council of Australia
This work was supported by the National Health and Medical Research Council of Australia, Project grant #611804 (to G.N. & L.J.F.R.), Fellowships #494808 (to G.N.) and #388901 (to L. A. S.), and by the Victorian Government's Operational Infrastructure Support Program.