Journal article

CX3CL1 and CCL14 regulate extracellular matrix and adhesion molecules in the trophoblast: Potential roles in human embryo implantation

Natalie J Hannan, Lois A Salamonsen

Biology of Reproduction | OXFORD UNIV PRESS INC | Published : 2008

Abstract

Embryo implantation is a complex process involving blastocyst attachment to the endometrial epithelium and subsequent trophoblast invasion of the decidua. We have previously shown that the chemokines CX3CL1 and CCL14 are abundant in endometrial vasculature, epithelial, and decidual cells at this time, and that their receptors, CX3CR1 and CCR1, are present on invading human trophoblasts. CX3CL1 and CCL14 promote trophoblast migration. We hypothesized that these endometrial chemokines promote trophoblast migration by regulating adhesion molecules and extracellular matrix (ECM) components on the trophoblast, similar to mechanisms used in leukocyte trafficking. Trophoblast cells (AC1M-88) used p..

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