Journal article

Identification of chemokines important for leukocyte recruitment to the human endometrium at the times of embryo implantation and menstruation

RL Jones, NJ Hannan, TJ Kaitu'u, J Zhang, LA Salamonsen

The Journal of Clinical Endocrinology & Metabolism | ENDOCRINE SOC | Published : 2004


Human endometrium possesses a unique immunological environment enabling implantation of the semiallogeneic embryo. Large populations of macrophages and uterine-specific natural killer cells infiltrate the implantation site, believed to be important modulators of trophoblast invasion and decidualization. In the absence of pregnancy, there is a dramatic influx of neutrophils, eosinophils, and macrophages, likely to be critical for focal inflammatory endometrial destruction. However, little is known regarding selective recruitment of leukocyte subtypes. We employed a gene array approach to analyze the expression of 21 chemokines in endometrium. Real-time RT-PCR and immunohistochemistry was cond..

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