Journal article

Cytokines and chemokines during human embryo implantation: Roles in implantation and early placentation

Lois A Salamonsen, Natalie J Hannan, Evdokia Dimitriadis

Seminars in Reproductive Medicine | THIEME MEDICAL PUBL INC | Published : 2007


The complex processes of embryo implantation and early placentation require a plethora of locally acting molecules, which are themselves tightly regulated. Among these are cytokines (including chemotactic chemokines), which are synthesized by several cell types at the maternal-fetal interface. Those produced by endometrial epithelium may be secreted apically into the uterine lumen, where they affect blastocyst development, migration, and attachment, or basally with effects on the transformation of the underlying stroma. Decidualized stromal cells, which subsequently form a major component of the decidua of pregnancy, also produce cytokines that act to drive the decidualization process and ch..

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