Journal article

Comprehensive genomic profiles of small cell lung cancer

Julie George, Jing Shan Lim, Se Jin Jang, Yupeng Cun, Luka Ozretic, Gu Kong, Frauke Leenders, Xin Lu, Lynnette Fernandez-Cuesta, Graziella Bosco, Christian Mueller, Ilona Dahmen, Nadine S Jahchan, Kwon-Sik Park, Dian Yang, Anthony N Karnezis, Dedeepya Vaka, Angela Torres, Maia Segura Wang, Jan O Korbel Show all

Nature | NATURE PUBLISHING GROUP | Published : 2015

Grants

Awarded by German Cancer Aid (Deutsche Krebshilfe) as part of the small cell lung cancer genome sequencing consortium


Awarded by Korea Research Foundation


Awarded by NIH


Awarded by German Ministry of Science and Education (BMBF)


Awarded by Deutsche Forschungsgemeinschaft (DFG)


Awarded by European Union as part of the PerMed NRW initiative


Awarded by EU


Awarded by Stand Up To Cancer-American Association of Cancer Research Innovative Research Grant


Awarded by National Cancer Center Research and Development Fund


Awarded by Italian Ministry of Health


Awarded by AIRC/MGAF



Awarded by NATIONAL CANCER INSTITUTE


Awarded by Grants-in-Aid for Scientific Research


Funding Acknowledgements

We are grateful to all the patients who contributed their tumour specimens. We thank the computing center of the University of Cologne (RRZK) for providing the CPU time on the DFG-funded supercomputer 'CHEOPS', as well as for the support. We thank S. Artavanis-Tsakonas and S. Fre for the gift of the mice with inducible NICD expression. We thank C. Nguyen, J. Berg, J. Heuckmann, F. Malchers, C. Lovely and A. Bernschein for scientific discussions and advice. We thank Genentech/gRED for providing raw sequencing data from a previously published study<SUP>3</SUP>. Some tumors in these studies were provided by the LungBiobank Heidelberg, member of the NCT-Tissue bank, the biomaterial bank Heidelberg and the biobank platform of the German Center for Lung Research, Heidelberg, Germany. This work was supported by the German Cancer Aid (Deutsche Krebshilfe) as part of the small cell lung cancer genome sequencing consortium (grant ID: 109679 to R.K.T., M.P., R.B., P.N., M.V. and S.A.H.). Further support was provided by the Korea Research Foundation (KRF 2011-0030105; grant to S. J. J.). Additional funding was provided by the NIH (5R01CA114102-08 to J. S.), the German Ministry of Science and Education (BMBF) as part of the NGFNplus program(grant 01GS08101 to R.K.T., J.W. and P.N.) and as part of the e:Med program (grant no. 01ZX1303A to R.K.T., J.W., C.R., R.B. and M.P. and grant no. 01ZX1406 to M.P.), by the Deutsche Forschungsgemeinschaft (DFG; through TH1386/3-1 to R.K.T and KFO-286 to P.N.), by the German federal state North Rhine Westphalia (NRW), by the European Union (European Regional Development Fund: Investing In Your Future) as part of the PerMed NRW initiative (grant 005-1111-0025 to R.K.T., J.W. and R.B.), by SFB832 (TP6 to R.K.T., TP5 to L.C.H.), by the Deutsche Krebshilfe as part of the Oncology Centers of Excellence funding program (to R.B., R.K.T. and M.S.), by the EU-Framework program CURELUNG (HEALTH-F2-2010-258677 to R.K.T., J.W., J.K.F., L.R., M.S.C. and E.B.), by Stand Up To Cancer-American Association of Cancer Research Innovative Research Grant (SU2C-AACR-IR60109 to R.K.T.), by the German Consortium for Translational Cancer Research (DKTK) Joint Funding program, by the National Cancer Center Research and Development Fund (NCC Biobank: 23A-1, to T.K., J.Y. and R. I.), by the Italian Ministry of Health (Ricerca Corrente RC1303LO57 and GR program 2010-2316264 to L.A.M.), by the Roy Castle Lung Cancer Foundation UK (to J.K.F.), by the AIRC/MGAF grant 12983 (to L.A.M.) and by A*STAR in Singapore (scholarship to J.S.L.). J. S. is the Harriet and Mary Zelencik Scientist in Children's Cancer and Blood Diseases.