Journal article

Impaired transendothelial migration of B-CLL lymphocytes: a defect linked to low L-selectin expression

B Gu, LP Dao, J Wiley

Leukemia & Lymphoma | HARWOOD ACAD PUBL GMBH | Published : 2001


The emigration of lymphocytes from blood into lymph nodes is regulated by the expression of the adhesion molecule, L-selectin on the lymphocyte surface which arrests the rolling of the cell on the vessel wall and allows firmer adhesive interactions to develop. The expression of L-selectin on B-CLL lymphocytes is less than half that on normal lymphocytes and this difference correlates with an impaired capacity of B-CLL lymphocytes to migrate beneath a monolayer of human umbilical vein endothelial cells. Both the B-cell and T-cell lymphocytes from normal subjects and B-CLL patients show down-regulation of L-selectin and CD23 after transendothelial migration. The reduced expression of L-selecti..

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