Taenia taeniaeformis in mice: Passive transfer of protection with sera from infected or vaccinated mice and analysis of serum antibodies to oncospheral antigens

Abstract

Passive transfer of immunity to Taenia taeniaeformis infection was investigated using sera either from mice protected against infection by vaccination with oncosphere antigen or from mice 28 days after infection (28 DPI) with eggs. Transfer of 0.2 ml serum from mice vaccinated with either freeze-thaw-sonicated oncospheres (TtO FTS) or solubilized oncospheres (TtO DOC) failed to provide protection against infection with larvae in the recipient mice despite the fact that the serum donors were completely protected against the development of any viable larvae from a challenge infection with eggs. Some transfer of protection was achieved using larger volumes of sera (0.25, 0.5 ml) from vaccinated..