Journal article

MU-CRYSTALLIN IS A MAMMALIAN HOMOLOG OF AGROBACTERIUM-ORNITHINE CYCLODEAMINASE AND IS EXPRESSED IN HUMAN RETINA

RY KIM, R GASSER, GJ WISTOW

Proceedings of the National Academy of Sciences of the United States of America | NATL ACAD PRESS | Published : 1992

Abstract

mu-Crystallin is the major component of the eye lens in several Australian marsupials. The complete sequence of kangaroo mu-crystallin has now been obtained by cDNA cloning. The predicted amino acid sequence shows similarity with ornithine cyclodeaminases encoded by the tumor-inducing (Ti) plasmids of Agrobacterium tumefaciens. Until now, neither ornithine cyclodeaminase nor any structurally related enzymes have been observed in eukaryotes. RNA analysis of kangaroo tissues shows that mu-crystallin is expressed at high abundance in lens, but outside the lens mu-crystallin is preferentially expressed in neural tissues, retina, and brain. An almost full-length cDNA for mu-crystallin was cloned ..

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University of Melbourne Researchers