Journal article

DETERMINATION OF THE OPTIMUM CUTOFF VALUE OF A DIAGNOSTIC-TEST

AL VIZARD, GA ANDERSON, RB GASSER

PREVENTIVE VETERINARY MEDICINE | ELSEVIER SCIENCE BV | Published : 1990

Abstract

Many diagnostic tests require the determination of cut-off values that discriminate uninfected from infected individuals. The cut-off values of a serodiagnostic test were calculated to minimize the total cost of misdiagnoses. Three different assumptions were made about the density distributions of the uninfected and infected populations to which the test was to be applied: (1) the population distributions were identical to the sample distributions; (2) both populations were normally distributed; (3) the population distributions may not be normal but may follow other density distributions that are used commonly. The cut-off values calculated using each assumption varied considerably. This ind..

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