Comparative genomic and proteomic analyses of two Mycoplasma agalactiae strains: clues to the macro- and micro-events that are shaping mycoplasma diversity
Laurent X Nouvel, Pascal Sirand-Pugnet, Marc S Marenda, Eveline Sagne, Valerie Barbe, Sophie Mangenot, Chantal Schenowitz, Daniel Jacob, Aurelien Barre, Stephane Claverol, Alain Blanchard, Christine Citti
BMC Genomics | BMC | Published : 2010
BACKGROUND: While the genomic era is accumulating a tremendous amount of data, the question of how genomics can describe a bacterial species remains to be fully addressed. The recent sequencing of the genome of the Mycoplasma agalactiae type strain has challenged our general view on mycoplasmas by suggesting that these simple bacteria are able to exchange significant amount of genetic material via horizontal gene transfer. Yet, events that are shaping mycoplasma genomes and that are underlining diversity within this species have to be fully evaluated. For this purpose, we compared two strains that are representative of the genetic spectrum encountered in this species: the type strain PG2 whi..View full abstract
This research was supported by grants from the Institute National de la Recherche Agronomique (AgroBI, INRA), the University Victor Segalen Bordeaux 2, and the Ecole Nationale Veterinaire de Toulouse.