Journal article

ROLE OF THE THYMUS IN THE GENERATION OF SKIN-HOMING ALPHA-BETA AND GAMMA-DELTA VIRGIN T-CELLS

EA WASHINGTON, WG KIMPTON, JE HOLDER, RNP CAHILL

EUROPEAN JOURNAL OF IMMUNOLOGY | VCH PUBLISHERS INC | Published : 1995

Abstract

Current models of lymphocyte traffic suggest that homing specificities of T cells to tissues such as skin are generated outside the thymus as a result of activation of naive T cells by antigen in lymph nodes. Virgin T cells are thought to home to high endothelial venules in lymph nodes, but are thought to be unable to home to extra-lymphoid tissues such as skin. We used the technique of in situ labeling of the thymus with fluorescein isothiocyanate to examine the homing specificities of authentically naive T cells in vivo, immediately after their export from the thymus. We report that homing specificities for skin as well as lymph node are imprinted on T cells inside the thymus, independent ..

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