Actions and interactions of ADP, 5-HT, histamine and PAF on equine platelets

Abstract

Platelets are thought to play a role in equine diseases such as acute laminitis and verminous arteritis and may be involved in allergic disease. Mediators implicated in the pathophysiology of these conditions activate platelets and responses may be enhanced by interactions between mediators. The present study compared platelet aggregation, thromboxane production and release of radiolabelled [3H]5-HT in response to 5-HT, histamine, ADP and PAF alone and in combination in vitro. PAF caused concentration-related aggregation, [3H]5-HT release and thromboxane production. In contrast, ADP caused aggregation and 5-HT induced the release of [3H]5-HT with little effect on other platelet functions. Hi..