Journal article

Therapeutic immunization against Helicobacter pylori infection in the absence of antibodies

P Sutton, J Wilson, T Kosaka, I Wolowczuk, A Lee

Immunology and Cell Biology | BLACKWELL SCIENCE ASIA | Published : 2000


Helicobacter pylori is an important human pathogen. Prophylactic immunization with bacterial antigen plus an adjuvant protects mice against challenge with live H. pylori. Surprisingly, it was found that immunizations of mice already infected with Helicobacter also influenced bacterial colonization. This concept of therapeutic immunization is a novel phenomenon. Because H. pylori lives in the lumen of the stomach, it was initially hypothesized that the protective mechanism would involve induction of secretory IgA. However, work with knockout mice has demonstrated that prophylactic immunization is equally effective in mice deficient in IgA and even in microMT mice lacking B lymphocytes. Curren..

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