Journal article

A genetic basis for atrophy: dominant non-responsiveness and helicobacter induced gastritis in F-1 hybrid mice

P Sutton, J Wilson, R Genta, D Torrey, A Savinainen, J Pappo, A Lee

Gut | BRITISH MED JOURNAL PUBL GROUP | Published : 1999

Abstract

BACKGROUND: The importance of host factors in helicobacter induced gastritis has been shown in animal models. Infection of most mouse strains with Helicobacter felis results in a functional atrophic gastritis, while other strains remain gastritis free. AIMS: To investigate these host factors further by using genetic crosses of responder and non-responder mice. METHODS: F(1) hybrids of the non-responder CBA/Ca strain and three strains of mice known to develop H felis induced gastritis were infected for three months with H felis. Gastritis was assessed by histopathology and serum antibody responses by ELISA. RESULTS: Infection of CBA/Ca mice and F(1) hybrids induced little or no gastritis. Ana..

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