A genetic basis for atrophy: Dominant non-responsiveness and helicobacter induced gastritis in F1 hybrid mice

Abstract

Background - The importance of host factors in helicobacter induced gastritis has been shown in animal models. Infection of most mouse strains with Helicobacter felis results in a functional atrophic gastritis, while other strains remain gastritis free. Aims - To investigate these host factors further by using genetic crosses of responder and non-responder mice. Methods - F1 hybrids of the non-responder CBA/Ca strain and three strains of mice known to develop H felis induced gastritis were infected for three months with H felis. Gastritis was assessed by histopathology and serum antibody responses by ELISA. Results - Infection of CBA/Ca mice and F1 hybrids induced little or no gastritis. Ana..