Journal article

TENASCIN IS A STROMAL MARKER FOR EPITHELIAL MALIGNANCY IN THE MAMMARY-GLAND

EJ MACKIE, R CHIQUETEHRISMANN, CA PEARSON, Y INAGUMA, K TAYA, Y KAWARADA, T SAKAKURA

Proceedings of the National Academy of Sciences of the United States of America | NATL ACAD PRESS | Published : 1987

Abstract

Tenascin is an extracellular matrix glycoprotein that is not present in the normal mature rat mammary gland. The distribution of tenascin was examined by immunohistochemistry in mammary tumors from carcinogen-treated and untreated rats, in virus-induced mammary tumors from mice, and in a variety of mammary gland lesions from humans. Tenascin was detectable in the stroma of the malignant but not of the benign tumors from all species. An inhibition ELISA, testing homogenates of rat tumors, confirmed that tenascin was present in malignant but not in benign tumors. Thus, tenascin was consistently found to be a stromal marker for epithelial malignancy in the mammary gland. It is concluded that te..

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