Immunosuppressive effects of cyclophosphamide in pigs

Abstract

Effects of cyclophosphamide (CY) on circulating leukocytes, lymphoid tissues, and antibody response of the pig were examined. Pigs (10 weeks old) were treated with intraperitoneal injections of 30 mg of CY/kg of body weight at 2-day intervals. Three CY injections depressed total leukocyte, neutrophil, and lymphocyte counts. Circulating B-lymphocyte percentages were depleted by 80% and absolute B-lymphocyte counts by 90%. Circulating T-lymphocyte percentages were not affected by CY treatment, but absolute T-cell counts were depressed by 50%. Lymphocytes were depleted from the cortex of the thymus gland and from the spleen and lymph nodes with a preferential effect on B-dependent areas. All th..