Journal article

TENASCIN IS ASSOCIATED WITH CHONDROGENIC AND OSTEOGENIC DIFFERENTIATION INVIVO AND PROMOTES CHONDROGENESIS INVITRO

EJ MACKIE, I THESLEFF, R CHIQUETEHRISMANN

JOURNAL OF CELL BIOLOGY | ROCKEFELLER UNIV PRESS | Published : 1987

Abstract

The tissue distribution of the extracellular matrix glycoprotein, tenascin, during cartilage and bone development in rodents has been investigated by immunohistochemistry. Tenascin was present in condensing mesenchyme of cartilage anlagen, but not in the surrounding mesenchyme. In fully differentiated cartilages, tenascin was only present in the perichondrium. In bones that form by endochondral ossification, tenascin reappeared around the osteogenic cells invading the cartilage model. Tenascin was also present in the condensing mesenchyme of developing bones that form by intramembranous ossification and later was present around the spicules of forming bone. Tenascin was absent from mature bo..

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University of Melbourne Researchers