Effect of sodium bicarbonate administration on renal function of horses

Abstract

Objectives-To describe changes in renal unction of horses after oral and IV administration of sodium bicarbonate (NaHCO3) and to determine whether changes are dose dependent. Animals-6 Standardbred mares. Procedure-Blood and urine samples for determination of renal function were collected immediately before and at hourly intervals for 12 hours after administration of each of 3 oral doses (1,500, 1,000, and 250 mg/kg of body weight, in 3 L of water) and 1 IV dose (250 mg/kg, 5% solution) of NaHCO3, or water (3 L orally). Results-NaHCO3 induced increases in urine flow; electrolyte-free water reabsorption; urine concentrations of sodium and bicarbonate; fractional excretion of sodium, potassium..