Journal article

Estrogen is not essential for full endometrial restoration after breakdown: Lessons from a mouse model

Tu'uhevaha J Kaitu'u-Lino, Naomi B Morison, Lois A Salamonsen

Endocrinology | ENDOCRINE SOC | Published : 2007


The current dogma surrounding endometrial regeneration after menses includes a critical need for estrogen-primed proliferation. Although some evidence suggests that estrogen may not be required for the initial reepithelialization of the uterine surface, it is widely believed that it is essential for successful stromal renewal. This study aimed to identify proliferating cell types during endometrial repair and to examine whether estrogen is required for successful repair using a previously developed mouse model. In the model, decidualization is artificially induced, and progesterone support withdrawn; the endometrial tissue progressively breaks down by 24 h after progesterone withdrawal and b..

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