A New Role for Activin in Endometrial Repair after Menses
Tu'uhevaha J Kaitu'u-Lino, David J Phillips, Naomi B Morison, Lois A Salamonsen
ENDOCRINOLOGY | ENDOCRINE SOC | Published : 2009
Abnormal uterine bleeding can severely affect the quality of life for women. After menstruation, the endometrium must adequately repair to limit and stop bleeding. Abnormal uterine bleeding may result from incorrect or inadequate endometrial repair after menstruation. Previous studies have shown an important contribution of activin to skin wound healing, with severely delayed wound repair observed in animals transgenically induced to overexpress activin's natural inhibitor, follistatin. Activin subunits have also been identified within human endometrium; however, their role in endometrial repair is unknown. We assessed the contribution of activin to endometrial repair after menses using a hu..View full abstract
Awarded by National Health and Medical Research Council of Australia
This work was funded by the National Health and Medical Research Council of Australia (388901, 241000, and 334011) and by an Australian Postgraduate Scholarship (to T. K.).