Simultaneous measurement of urinary albumin and total protein may facilitate decision-making in HIV-infected patients with proteinuria
A Samarawickrama, M Cai, ER Smith, K Nambiar, C Sabin, M Fisher, Y Gilleece, SG Holt
HIV Medicine | WILEY-BLACKWELL | Published : 2012
OBJECTIVE: We recently showed that a urine albumin/total protein ratio (uAPR) 30 mg/mmol) into two groups: those with predominantly 'tubular' proteinuria (TP) (uAPR <0.4) and those with predominantly 'glomerular' proteinuria (GP) (uAPR ≥ 0.4). RESULTS: A total of 618 of 5244 samples from 1378 patients had uPCR ≥ 30 mg/mmol. uAPRs were available in 144 patients: 46 patients (32%) had TP and 21 (15%) GP; the remainder had uPCR <30 mg/mmol. The TP group had a higher fractional excretion of phosphate compared with the GP group (mean 27% vs. 16%, respectively; P100 mg/mmol), a renal assessment was made; eight had a kidney biopsy. In all cases, the uAPR results correlated with the nephrological di..View full abstract
AS has received travel bursaries and scholarships from Boehringer Ingelheim, Bristol Myers Squib, Gilead, Merck Sharp and Dohme, Tibotec and Viiv Healthcare. KN has received funding for travel, consultancies and teaching purposes from Bristol Myers Squibb, Gilead Sciences and Viiv Healthcare. CS has received funding for travel, consultancies and teaching purposes from Gilead Sciences, Bristol Myers Squibb and Janssen-Cilag. MF has received honoraria and/or travelling scholarships from Abbott, Bristol Myers Squibb, Gilead, Janssen, Merck and Viiv Healthcare. YG has received travel bursaries and educational grants from Abbott, Gilead, Tibotec and Viiv Healthcare. SH has received honoraria from Gilead in the past.