Calcium channel blockers for inhibiting preterm labour and birth.
Vicki Flenady, Aleena M Wojcieszek, Dimitri NM Papatsonis, Owen M Stock, Linda Murray, Luke A Jardine, Bruno Carbonne
Cochrane Database of Systematic Reviews | Published : 2014
BACKGROUND: Preterm birth is a major contributor to perinatal mortality and morbidity, affecting around 9% of births in high-income countries and an estimated 13% of births in low- and middle-income countries. Tocolytics are drugs used to suppress uterine contractions for women in preterm labour. The most widely used tocolytic are the betamimetics, however, these are associated with a high frequency of unpleasant and sometimes severe maternal side effects. Calcium channel blockers (CCBs) (such as nifedipine) may have similar tocolytic efficacy with less side effects than betamimetics. Oxytocin receptor antagonists (ORAs) (e.g. atosiban) also have a low side-effect profile. OBJECTIVES: To ass..View full abstract