Journal article

EFFECT OF STRESS ON TISSUE AND PLASMA-LEVELS OF IMMUNOREACTIVE BETA-ENDORPHIN IN OVARIECTOMIZED RATS PRIMED WITH ESTROGEN AND PROGESTERONE

GK HULSE, GJ COLEMAN

JOURNAL OF ENDOCRINOLOGY | J ENDOCRINOLOGY LTD | Published : 1984

Abstract

The aim of this study was to investigate the effect of oestrogen and progesterone on levels of immunoreactive beta-endorphin (Ir-beta-EP) in the hypothalamus, anterior pituitary gland, neurointermediate lobe and plasma under normal conditions and conditions of stress. The injection of oestrogen + progesterone into ovariectomized rats increased Ir-beta-EP levels in extracts of anterior pituitary tissue and in plasma, under both normal and stressed conditions. Exposure to a stress reduced the content of anterior pituitary Ir-beta-EP in ovariectomized rats treated with oestrogen + progesterone and also with sesame oil. Such treatment only resulted in increments in plasma Ir-beta-Ep in oil-treat..

View full abstract