Journal article

ESSENTIAL FATTY-ACIDS IN THE TREATMENT OF PREMENSTRUAL-SYNDROME

A COLLINS, A CERIN, G COLEMAN, BM LANDGREN

OBSTETRICS AND GYNECOLOGY | LIPPINCOTT WILLIAMS & WILKINS | Published : 1993

Abstract

OBJECTIVE: To determine whether essential fatty acids are effective in the treatment of premenstrual syndrome (PMS). METHODS: In a randomized, double-blind, crossover trial, we studied 27 women diagnosed with PMS over ten menstrual cycles and 22 symptom-free controls over one cycle. The first cycle was used for diagnostic assessment. For the women with PMS, placebos were administered during the second cycle. This was followed by randomization to four cycles of active treatment with essential fatty acids and four cycles of placebo, with a crossover after completion of the fourth cycle. Assessment of symptoms and diagnosis of PMS were based on daily self-ratings made by the women throughout th..

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