Lipid and small-molecule display by CD1 and MR1

Ildiko Van Rhijn; Dale I Godfrey; Jamie Rossjohn; D Branch Moody

Journal article

Lipid and small-molecule display by CD1 and MR1

Ildiko Van Rhijn, Dale I Godfrey, Jamie Rossjohn, D Branch Moody

NATURE REVIEWS IMMUNOLOGY | NATURE PUBLISHING GROUP | Published : 2015

DOI: 10.1038/nri3889

Abstract

The antigen-presenting molecules CD1 and MHC class I-related protein (MR1) display lipids and small molecules to T cells. The antigen display platforms in the four CD1 proteins are laterally asymmetrical, so that the T cell receptor (TCR)-binding surfaces are comprised of roofs and portals, rather than the long grooves seen in the MHC antigen-presenting molecules. TCRs can bind CD1 proteins with left-sided or right-sided footprints, creating unexpected modes of antigen recognition. The use of tetramers of human CD1a, CD1b, CD1c or MR1 proteins now allows detailed analysis of the human T cell repertoire, which has revealed new invariant TCRs that bind CD1b molecules and are different from tho..

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University of Melbourne Researchers

Dale Godfrey Author Microbiology and Immunology

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Grants

Awarded by National Institute of Allergy and Infectious Diseases (NIAID)

Awarded by National Health and Medical Research Council (NHMRC) of Australia

Awarded by Australian Research Council

Awarded by Cancer Council of Victoria

Awarded by NHMRC

Awarded by NHMRC Australia Fellowship

Funding Acknowledgements

The authors thank R. Birkinshaw, J. Le Nours, S. Huang, T.-Y. Cheng and K. Wucherpfennig for advice and graphical images. This work is supported by the Bill and Melinda Gates Foundation, National Institute of Allergy and Infectious Diseases (NIAID; grants AI049313, AI111224 and U19 111224), National Health and Medical Research Council (NHMRC) of Australia (1013667 and 1083942), Australian Research Council (DP140100977 and CE140100011), Cancer Council of Victoria (1042866), NHMRC Senior Principal Research Fellowship (to D.I.G.; 1020770) and NHMRC Australia Fellowship (to J.R.; AF50). All figures, including figure 1 and figure 5b, are original.