Journal article
Bone marrow lesions can be subtyped into groups with different clinical outcomes using two magnetic resonance imaging (MRI) sequences
AE Wluka, AJ Teichtahl, R Maulana, BM Liu, Y Wang, GG Giles, R O'Sullivan, D Findlay, FM Cicuttini
Arthritis Research and Therapy | Published : 2015
Abstract
Introduction: Bone marrow lesions (BMLs) are features detected on MRI that are important in the pathogenesis of knee osteoarthritis. Since BMLs reflect heterogeneous pathologies this prospective cohort study examined whether BMLs detected using different MRI sequences are associated with distinct structural and clinical endpoints. Methods: A total of 297 community-based adults without knee pain were examined to identify BMLs visualised using three-dimensional T1-weighted gradient-echo fat-suppressed (T1-weighted sequences) fat-suppressed and fat-saturated FSE T2-weighted MRI sequences (T2-weighted sequences) at baseline. Cartilage volume was measured at baseline and follow-up, while incident..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
This study was supported by NHMRC Project Grant 1042482. AEW is the recipient of a National Health and Medical Research Council (NHMRC) Career Development Fellowship (Clinical Level 2 1063574). AJT is the recipient of the NHMRC Early Career Fellowship (1073284). YW is the recipient of an NHMRC Career Development Fellowship (Clinical Level 1 1065464). This study was funded by NHMRC Project Grant 1042482.