Journal article

FETAL ORIGIN OF TRANSFERRIN IN MOUSE AMNIOTIC-FLUID

MB RENFREE, A MCLAREN

NATURE | MACMILLAN MAGAZINES LTD | Published : 1974

Abstract

THE measurement of specific foetal products in amniotic fluid collected after amniocentesis offers an obvious approach to the foetus in utero. The proteins in mouse amniotic fluid consist of three transferrins (Trf1, 2 and 3), five α foetoproteins (α FP 1-5) and albumins, the proportions of which change during gestation1,2. The changes in composition directly parallel those observed in foetal serum, except that they occur 24 h later in the amniotic fluid. No comparable alteration is observed in maternal serum patterns. Transferrin 3 constitutes the major transferrin band both in late-stage foetuses and in adults, and so could be derived from either the foetus or the mother. We have investiga..

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University of Melbourne Researchers