Roles of ligands from the TNF superfamily in B cell development, function, and regulation
William A Figgett, Fabien B Vincent, Damien Saulep-Easton, Fabienne Mackay
Seminars in Immunology | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | Published : 2014
Most ligands from the tumour necrosis factor (TNF) superfamily play very important roles in the immune system, and particularly so in B lymphocyte biology. TNF ligands are essential to many aspects of normal B cell biology from development in the bone marrow to maturation in the periphery as well as for activation and differentiation into germinal centre, memory or plasma cells. TNF ligands also influence other aspects of B cell biology such as their ability to present antigens or regulate immune responses. Importantly, inadequate regulation of many TNF ligands is associated with B cell disorders including autoimmunity and cancers. As a result, inhibitors of a number of TNF ligands have been..View full abstract
Awarded by National Health and Medical Research Council of Australia
F. Mackay is supported by the National Health and Medical Research Council of Australia (program grant APP1016953).