Journal article
CXC chemokine receptor 7 (CXCR7) regulates CXCR4 protein expression and capillary tuft development in mouse kidney
S Haege, C Einer, S Thiele, W Mueller, S Nietzsche, A Lupp, F Mackay, S Schulz, R Stumm
Plos One | Published : 2012
Abstract
Background: The CXCL12/CXCR4 axis is involved in kidney development by regulating formation of the glomerular tuft. Recently, a second CXCL12 receptor was identified and designated CXCR7. Although it is established that CXCR7 regulates heart and brain development in conjunction with CXCL12 and CXCR4, little is known about the influence of CXCR7 on CXCL12 dependent kidney development. Methodology/Principal Findings: We provided analysis of CXCR7 expression and function in the developing mouse kidney. Using in situ hybridization, we identified CXCR7 mRNA in epithelial cells including podocytes at all nephron stages up to the mature glomerulus. CXCL12 mRNA showed a striking overlap with CXCR7 m..
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Awarded by DFG
Funding Acknowledgements
The study was supported by the Jena University grant program for young academics (to SH) and DFG grant STUw295-5/1 (to RS). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.