CXCR7 prevents excessive CXCL12-mediated downregulation of CXCR4 in migrating cortical interneurons
Philipp Abe, Wiebke Mueller, Dagmar Schuetz, Fabienne MacKay, Marcus Thelen, Penglie Zhang, Ralf Stumm
Development | COMPANY BIOLOGISTS LTD | Published : 2014
The CXCL12/CXCR4 signaling pathway is involved in the development of numerous neuronal and non-neuronal structures. Recent work established that the atypical second CXCL12 receptor, CXCR7, is essential for the proper migration of interneuron precursors in the developing cerebral cortex. Two CXCR7-mediated functions were proposed in this process: direct modulation of β-arrestin-mediated signaling cascades and CXCL12 scavenging to regulate local chemokine availability and ensure responsiveness of the CXCL12/CXCR4 pathway in interneurons. Neither of these functions has been proven in the embryonic brain. Here, we demonstrate that migrating interneurons efficiently sequester CXCL12 through CXCR7..View full abstract
Awarded by Deutsche Forschungsgemeinschaft (DFG)
The work was supported by the Deutsche Forschungsgemeinschaft (DFG) [grant STU 295/7-1].