Journal article

Focus on systemic lupus erythematosus in Indigenous Australians: towards a better understanding of autoimmune diseases

FB Vincent, P Bourke, EF Morand, F Mackay, D Bossingham

Internal Medicine Journal | WILEY-BLACKWELL | Published : 2013

Abstract

The incidence and prevalence of autoimmune diseases such as rheumatoid arthritis, primary Sjögren syndrome, scleroderma and systemic lupus erythematosus (SLE) varies with geography and ethnicity. For example, SLE is reported to be more common in populations such as African-Caribbeans and Indigenous Australians (IA). As well as socio-economic status, variation in severity of disease may also show ethnic variability. The initial presentation of SLE in IA, in the context of a unique genetic background and distinctive environmental influences, is often florid with a recurring spectrum of clinical phenotypes. These clinical observations suggest a unique pathway for autoimmunity pathogenesis in th..

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University of Melbourne Researchers