Journal article

ENDOCRINE RESPONSES OF FETAL SHEEP TO PROLONGED HYPOXEMIA WITH AND WITHOUT ACIDEMIA - RELATION TO URINE PRODUCTION

ME WLODEK, RA BRACE, ML COCK, SB HOOPER, R HARDING

American Journal of Physiology | AMER PHYSIOLOGICAL SOC | Published : 1995

Abstract

Our aim was to examine the endocrine changes associated with alterations in fetal urine production during 24 h of hypoxemia induced by either reduced uterine blood flow (RUBF) or maternal N2 inhalation (N2). In contrast to RUBF, which caused a diuresis, N2 caused a transient antidiuresis; during both posthypoxemia periods (RUBF and N2), fetal urine production was increased. RUBF, but not N2, was associated with a transient acidemia. Fetal plasma arginine vasopressin (AVP) and atrial natriuretic factor (ANF) concentrations increased during RUBF and were inversely correlated to pH; there were no detectable AVP or ANF responses to N2. Fetal prostaglandin E2 (PGE2) increased during the hypoxemia..

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