The role of the renal afferent and efferent nerve fibers in heart failure
Lindsea C Booth, Clive N May, Song T Yao
FRONTIERS IN PHYSIOLOGY | FRONTIERS MEDIA SA | Published : 2015
Renal nerves contain afferent, sensory and efferent, sympathetic nerve fibers. In heart failure (HF) there is an increase in renal sympathetic nerve activity (RSNA), which can lead to renal vasoconstriction, increased renin release and sodium retention. These changes are thought to contribute to renal dysfunction, which is predictive of poor outcome in patients with HF. In contrast, the role of the renal afferent nerves remains largely unexplored in HF. This is somewhat surprising as there are multiple triggers in HF that have the potential to increase afferent nerve activity, including increased venous pressure and reduced kidney perfusion. Some of the few studies investigating renal affere..View full abstract
This work was supported by National Health and Medical Research Council of Australia (NHMRC) and the Victorian Government's Operational Infrastructure Support Program. LB is supported by a NHMRC Early Career Fellowship and CM was supported by a NHMRC Research Fellowship.