Journal article

Primary end-point times, functional outcome and adverse event profile after acute ischaemic stroke

M Ali, RL Sacco, KR Lees

International Journal of Stroke | WILEY-BLACKWELL PUBLISHING, INC | Published : 2009

Abstract

BACKGROUND: Poststroke complications such as pulmonary embolism, deep vein thrombosis and pneumonia can impact outcome by causing deterioration in general health, delaying or preventing rehabilitation. While stroke carries a direct risk of complications, some events may be unrelated to index stroke severity and could confound outcome. We examined whether the presence of complications 'unrelated' to index stroke at later time-points could confound outcome, and if this could be minimised through altering study end-points. METHODS: We analysed 531 placebo-treated patients from the Virtual International Stroke Trials Archive who had experienced an acute ischaemic stroke and at least one poststro..

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