Journal article
Accuracy of an HRP-2/panLDH rapid diagnostic test to detect peripheral and placental Plasmodium falciparum infection in Papua New Guinean women with anaemia or suspected malaria
AJ Umbers, HW Unger, A Rosanas-Urgell, RA Wangnapi, JH Kattenberg, S Jally, S Silim, E Lufele, S Karl, M Ome-Kaius, LJ Robinson, SJ Rogerson, I Mueller
Malaria journal | Published : 2015
Abstract
BACKGROUND: The diagnosis of malaria during pregnancy is complicated by placental sequestration, asymptomatic infection, and low-density peripheral parasitaemia. Where intermittent preventive treatment (IPT) with sulfadoxine-pyrimethamine is threatened by drug resistance, or is inappropriate due to low transmission, intermittent screening and treatment (ISTp) with rapid diagnostic tests for malaria (RDT) could be a valuable alternative. Therefore, the accuracy of RDTs to detect peripheral and placental infection was assessed in a declining transmission setting in Papua New Guinea (PNG). METHODS: The performance of a combination RDT detecting histidine-rich protein-2 (HRP-2) and Plasmodium la..
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Awarded by Bill and Melinda Gates Foundation
Funding Acknowledgements
The authors wish to thank all the women and their families who participated in the study, and the staff at PNG Institute of Medical Research, Modilon General Hospital, and other participating health centres. This research was supported by the Malaria in Pregnancy Consortium, which is funded through a grant (46099) from the Bill and Melinda Gates Foundation to the Liverpool School of Tropical Medicine; the Pregvax Consortium, through a grant from the European Union's Seventh Framework Programme FP7-2007-HEALTH (PREGVAX 201588), and Pfizer Inc (investigator-initiated research grant WS394663). LJR and SK received a National Health and Medical Research Council (NHMRC) Early Career Fellowships (#1016443 and #1052960), and IM received an NHMRC Senior Research Fellowship (#1043345). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.