Journal article

Fatty acid composition of the postmortem prefrontal cortex of patients with schizophrenia, bipolar disorder, and major depressive disorder

Kei Hamazaki, Motoko Maekawa, Tomoko Toyota, Brian Dean, Tomohito Hamazaki, Takeo Yoshikawa

Psychiatry Research | ELSEVIER IRELAND LTD | Published : 2015

Abstract

Postmortem brain studies have shown abnormal levels of n-3 polyunsaturated fatty acids (PUFAs), especially docosahexaenoic acid, in the frontal cortex (particularly the orbitofrontal cortex) of patients with depression, schizophrenia, or bipolar disorder. However, the results from regions in the frontal cortex other than the orbitofrontal cortex are inconsistent. In this study we investigated whether patients with schizophrenia, bipolar disorder, or major depressive disorder have abnormalities in PUFA levels in the prefrontal cortex [Brodmann area (BA) 8]. In postmortem studies, fatty acids in the phospholipids of the prefrontal cortex (BA8) were evaluated by thin layer chromatography and ga..

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Grants

Awarded by Grants-in-Aid for Scientific Research


Funding Acknowledgements

We are grateful to Ms. Shizuko Takebe (University of Toyama) for her technical assistance and Ms. Mika Kigawa (University of Toyama) for her statistical assistance. We thank Drs. Ken-ichi Moto and Toshihide Kobayashi (RIKEN Lipid Biology Laboratory) for their technical advice. The Victorian Brain Bank Network is supported by the Florey Institute for Neuroscience and Mental Health, the Alfred Hospital, the Victorian Forensic Institute of Medicine, and the University of Melbourne, and funded by Australia's National Health and Medical Research Council, Helen Macpherson Smith Trust, and Parkinson's Victoria and Perpetual Philanthropic Services.