Journal article

A Role for Estrogen in Schizophrenia: Clinical and Preclinical Findings

Andrea Gogos, Alyssa M Sbisa, Jeehae Sun, Andrew Gibbons, Madhara Udawela, Brian Dean

International Journal of Endocrinology | HINDAWI LTD | Published : 2015

Abstract

Gender differences in schizophrenia have been extensively researched and it is being increasingly accepted that gonadal steroids are strongly attributed to this phenomenon. Of the various hormones implicated, the estrogen hypothesis has been the most widely researched one and it postulates that estrogen exerts a protective effect by buffering females against the development and severity of the illness. In this review, we comprehensively analyse studies that have investigated the effects of estrogen, in particular 17β-estradiol, in clinical, animal, and molecular research with relevance to schizophrenia. Specifically, we discuss the current evidence on estrogen dysfunction in schizophrenia pa..

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