Journal article
Rapid kit-based 68Ga-labelling and PET imaging with THP-Tyr3-octreotate: a preliminary comparison with DOTA-Tyr3-octreotate
MT Ma, C Cullinane, K Waldeck, P Roselt, RJ Hicks, PJ Blower
Ejnmmi Research | Published : 2015
Abstract
Background: Ge/68Ga generators provide an inexpensive source of a PET isotope to hospitals without cyclotron facilities. The development of new 68Ga-based molecular imaging agents and subsequent clinical translation would be greatly facilitated by simplification of radiochemical syntheses. We report the properties of a tris(hydroxypyridinone) conjugate of the SSTR2-targeted peptide, Tyr3-octreotate (TATE), and compare the 68Ga-labelling and biodistribution of [68Ga(THP-TATE)] with the clinical radiopharmaceutical [68Ga(DOTATATE)]. Methods: A tris(hydroxypyridinone) with a pendant isothiocyanate group was conjugated to the primary amine terminus of H2N-PEG2-Lys(iv-Dde)5-TATE, and the resultin..
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Awarded by Engineering and Physical Sciences Research Council
Funding Acknowledgements
MTM acknowledges the support of the People Programme (Marie Curie Actions) of the European Union's Seventh Framework Programme (FP7/2007-2013) under REA grant agreement number 299009, and the Royal Society of Chemistry through a Researcher Mobility Fellowship. We thank Wayne Noonan, Kerry Ardley, Susan Jackson and Rachael Walker for expert technical support. We thank David C. Muller (Genetic Epidemiology Group, International Agency for Research on Cancer) for his statistical advice and support. This research was supported by the Centre of Excellence in Medical Engineering Centre funded by the Wellcome Trust and EPSRC under grant number WT088641/Z/09/Z, the King's College London and UCL Comprehensive Cancer Imaging Centre funded by Cancer Research UK and EPSRC in association with the MRC and DoH (England), and by the National Institute for Health Research (NIHR) Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust and King's College London. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health.