Journal article
CAR-T cells are serial killers
AJ Davenport, MR Jenkins, DS Ritchie, HM Prince, JA Trapani, MH Kershaw, PK Darcy, PJ Neeson
Oncoimmunology | Published : 2015
Abstract
Chimeric antigen receptor (CAR) T cells have enjoyed unprecedented clinical success against haematological malignancies in recent years. However, several aspects of CAR T cell biology remain unknown. We recently compared CAR and T cell receptor (TCR)-based killing in the same effector cell and showed that CAR T cells can not only efficiently kill single tumor targets, they can also kill multiple tumor targets in a sequential manner. Single and serial killing events were not sustained long term due to CAR down-regulation after 20 hours.
Grants
Awarded by National Health and Medical Research Council