Towards the quantification of the proteostasis capacity of a cell

Abstract

How proteins are able to remain properly folded with precise control over their location and activity in the highly crowded cellular environment is one of the miracles of life. Quality control networks govern the life of each protein from synthesis and folding to transport and eventual degradation. However, the capacity of the proteostasis network to recover or overcome protein misfolding or aggregation is not fixed. Instead, it is influenced by environmental stresses, controlled by signalling networks and can be severely compromised by pathogenic proteins such as those seen in neurodegenerative diseases. Here, we present a new biosensor‐based approach to quantitate the proteostasis capacity..