Journal article

ARTERIOLAR SMOOTH-MUSCLE RESPONSES ARE MODULATED BY AN INTRAMURAL DIFFUSION BARRIER

MJ LEW, RJ RIVERS, BR DULING

American Journal of Physiology-Heart and Circulatory Physiology | AMER PHYSIOLOGICAL SOC | Published : 1989

Abstract

Arterioles (40-80 micron diameter) were isolated from the hamster cheek pouch, cannulated at both ends, and perfused with 3-(N-morpholino)propanesulfonic acid (MOPS)-buffered physiological salt solution (PSS). The vessels were observed with an inverted microscope and video system, and arteriolar diameter was measured. Arterioles were found to be 100 times more responsive to the alpha 1-adrenoceptor agonist phenylephrine when applied to the adventitial surface than when applied to the luminal surface. In contrast, SKF 89748-A, also an alpha 1-adrenoceptor selective agonist, but with a much greater lipid solubility than phenylephrine, was equipotent from either surface of the arteriole. We hyp..

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