Neuropsychological and olfactory dysfunction in schizophrenia: relationship of frontal syndromes to syndromes of schizophrenia

Abstract

Behavioural changes and cognitive impairments in schizophrenia have been linked to disturbances of complex neural networks involving both frontal and subcortical systems. Current literature has emphasised the role of the dorso-lateral prefrontal cortex (DLPFC) and its connections with hippocampus in the pathogenesis of schizophrenia. Based on a review of the literature, this paper examines other possible prefrontal areas that contribute to the manifestations of schizophrenia. We focus on the orbito-frontal cortex (OFC) and argue that it also plays an important role in the behavioural manifestations, symptoms and cognitive impairments observed in schizophrenia. The importance of fronto-striat..