THE CONTRIBUTION OF MACROLIDE RESISTANCE MUTATIONS TO FAILURE OF AZITHROMYCIN TREATMENT IN MYCOPLASMA GENITALIUM INFECTION

Abstract

Current recommended treatment for Mycoplasma genitalium (Mg) is azithromycin. Macrolide resistance mutations (MRM), predominantly on the 23SrRNA gene of Mg, have been found to be associated with failure of azithromycin. We aimed to determine the efficacy of 1g-azithromycin in a prospective cohort of Mg-infected STI clinic attendees, and to determine the contribution of MRM to treatment failure. We commenced an observational study in July 2012 in which symptomatic patients diagnosed with Mg by PCR at Melbourne Sexual Health Centre are retested for Mg 14 and 28 days following treatment with 1g-azithromycin. Testing for MRM using high-resolution melt analysis (HRM) is conducted on day 0 and on ..